KMID : 0988920210190020206
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Intestinal Research 2021 Volume.19 No. 2 p.206 ~ p.216
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Colitis and Crohn¡¯s Foundation (India): a first nationwide inflammatory bowel disease registry
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Sood Ajit
Kaur Kirandeep Mahajan Ramit Midha Vandana Singh Arshdeep Sharma Sarit Puri Amarender Singh Goswami Bhabhadev Desai Devendra Pai C. Ganesh
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Abstract
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Background/Aims: The national registry for inflammatory bowel disease (IBD) was designed to study epidemiology and prescribing pattern of treatment of IBD in India.
Methods: A multicenter, cross-sectional, prospective registry was established across four geographical zones of India. Adult patients with ulcerative colitis (UC) or Crohn¡¯s disease (CD) were enrolled between January 2014 and December 2015. Information related to demographics; disease features; complications; and treatment history were collected and analyzed.
Results: A total of 3,863 patients (mean age, 36.7 ¡¾ 13.6 years; 3,232 UC [83.7%] and 631 CD [16.3%]) were enrolled. The majority of patients with UC (n = 1,870, 57.9%) were from north, CD was more common in south (n = 348, 55.5%). The UC:CD ratio was 5.1:1. There was a male predominance (male:female = 1.6:1). The commonest presentation of UC was moderately severe (n = 1,939, 60%) and E2 disease (n = 1,895, 58.6%). Patients with CD most commonly presented with ileocolonic (n = 229, 36.3%) inflammatory (n = 504, 79.9%) disease. Extraintestinal manifestations were recorded among 13% and 20% of patients in UC and CD respectively. Less than 1% patients from both cohorts developed colon cancer (n = 26, 0.7%). The commonly used drugs were 5-aminosalicylates (99%) in both UC and CD followed by azathioprine (34.4%). Biologics were used in only 1.5% of patients; more commonly for UC in north and CD in south.
Conclusions: The national IBD registry brings out diversities in the 4 geographical zones of India. This will help in aiding research on IBD and improving quality of patient care.
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KEYWORD
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Inflammatory bowel disease, National registry, Colitis, ulcerative, India, Crohn disease
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